Skin irritation and corrosion toxicity tests: OECD Guidance 439
The safety assessment of products that come into direct contact with the skin is essential for reasons of legal compliance, especially with regard to human health. At the top of these assessments are skin irritation and corrosion toxicity tests.
The OECD 439 skin irritation test, developed as an alternative to animal testing, is often preferred due to its scientific validity and regulatory compliance.
What is OECD 439?
OECD 439 is an in vitro test guide designed to evaluate the skin irritation potential of chemicals and products. The test is performed using reconstituted human epidermis (RhE) models that mimic the human epidermis.
This method offers a reliable alternative, especially in areas where animal testing is restricted or prohibited.
The difference between skin irritation and corrosion
Skin irritation: Reversible redness, swelling and irritation of the skin
Skin corrosion: irreversible tissue damage that penetrates into the lower layers of the skin
OECD 439 is used to determine irritation, while corrosion assessment is usually supported by methods such as OECD 430, 431 or 435.
Application steps of the OECD 439 test method
- Application of the
- Test substance on the RhE model
- Removing the sample after the specified contact time has elapsed
- Measurement of cell viability by metabolic tests
- Evaluation of results against thresholds
- The determined cell viability rates determine whether the product is classified as skin irritant or not.
What products is OECD 439 used for?
- Cosmetics and personal care products
- Biocidal products
- Cleaning and laundry detergents
- Industrial Chemicals
- substances that can be used with medical devices in
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In this respect, OECD 439 forms the basis for safety assessment in numerous industries.
Benefits of the OECD 439 Test
- Alternative to animal testing and ethical approach
- High repeatability
- Short test duration
- Cost-effective solution
- Internationally recognized method
The OECD 439 Skin Irritation Test is an important part of modern toxicology and provides a scientific and compliant assessment to protect human health.
Please contact us for all the test details, the requirements for the approval of your products, and the full process.
info@nano-test.de