{"id":2247,"date":"2025-06-23T14:42:41","date_gmt":"2025-06-23T14:42:41","guid":{"rendered":"https:\/\/nano-test.de\/?p=2247"},"modified":"2025-07-01T11:10:58","modified_gmt":"2025-07-01T11:10:58","slug":"oecd-474-mammalian-eritrosit-mikronukleustest","status":"publish","type":"post","link":"https:\/\/nano-test.de\/fr\/2025\/06\/23\/oecd-474-mammalian-eritrosit-mikronukleustest\/","title":{"rendered":"Directives de test OCDE 474 & #8211 ; \u00c9rythrosite mammif\u00e8re"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2247\" class=\"elementor elementor-2247\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-24a635ae ts-col-stretched-none ts-bg-color-over-image elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"24a635ae\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5b0f00ff ts-bg-color-over-image\" data-id=\"5b0f00ff\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-62503973 elementor-widget elementor-widget-text-editor\" data-id=\"62503973\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Ligne directrice de test OCDE 474 : Qu\u2019est-ce que le test du micronoyau des \u00e9rythrocytes chez les mammif\u00e8res ?<\/h2><p>Zur Bewertung der Sicherheit neu entwickelter pharmazeutischer, biozider oder anderer chemischer Produkte f\u00fcr die Gesundheit von Mensch und Umwelt werden verschiedene toxikologische Tests durchgef\u00fchrt. Einer dieser Tests ist die OECD-Testrichtlinie 474<b>\u00a0\u2013 S\u00e4ugetier-Erythrozyten-Mikronukleus-Test<\/b>.<\/p><p>Dieser im Rahmen der <a href=\"https:\/\/nano-test.de\/fr\/service\/gute-laborpraxis-glp\/\">GLP (Gute Laborpraxis)<\/a> durchgef\u00fchrte Test wird insbesondere verwendet, um das Potenzial von Produkten zur Sch\u00e4digung des genetischen Materials, d. h. das <b>Genotoxizit\u00e4tsrisiko<\/b>, aufzuzeigen.<\/p><h3>Objectif du test du micronoyau \u00e9rythrocytaire chez les mammif\u00e8res<\/h3><p>Ce test examine la formation de micronoyaux (petites structures nucl\u00e9aires anormales) dans les \u00e9rythrocytes \u00e0 partir de la moelle osseuse ou du sang p\u00e9riph\u00e9rique afin de d\u00e9tecter des l\u00e9sions chromosomiques. Les micronoyaux se forment par une s\u00e9paration incorrecte de chromosomes ou de fragments de chromosomes lors de la division cellulaire et sont consid\u00e9r\u00e9s comme un indicateur de dommages g\u00e9n\u00e9tiques.<\/p><ul><li>Ce test est particuli\u00e8rement pr\u00e9f\u00e9r\u00e9 dans les cas suivants :<\/li><li>Processus de d\u00e9veloppement des produits pharmaceutiques<\/li><li>\u00c9valuations de s\u00e9curit\u00e9 des produits biocides et pesticides<\/li><li>Essais toxicologiques des produits chimiques industriels<\/li><li>\u00c9tuis obligatoires pour les cosm\u00e9tiques ou produits de soins personnels<\/li><\/ul><h3>Processus de candidature selon la TG 474 de l\u2019OCDE<\/h3><p>Le test du micronoyau r\u00e9alis\u00e9 conform\u00e9ment aux normes GLP comprend les \u00e9tapes suivantes :<\/p><ol><li><b>Vorbereitung der zu testenden Substanz:<\/b>Das Produkt wird unter Festlegung geeigneter L\u00f6sungsmittel und Dosierungsbereiche vorbereitet.<\/li><li><b>Verwendung von Versuchstieren:<\/b>In der Regel werden M\u00e4use oder Ratten verwendet. Vor Beginn der Arbeit wird die Genehmigung der Ethikkommission eingeholt.<\/li><li><b>Exposition:<\/b> Die Testsubstanz wird den Tieren oral, dermal oder durch Inhalation verabreicht.<\/li><li><b>Probenahme:<\/b> Nach einer bestimmten Zeit werden Erythrozytenproben aus dem Knochenmark oder peripherem Blut entnommen.<\/li><li><b>Mikronukleus-Analyse:<\/b> Die Erythrozyten werden unter dem Mikroskop untersucht. Die H\u00e4ufigkeit der Mikronukleusbildung wird bestimmt.<\/li><li><b>Auswertung der Ergebnisse:<\/b> Es wird ein Vergleich mit der Kontrollgruppe durchgef\u00fchrt und eine statistische Analyse vorgenommen.<\/li><\/ol><h3>Pour quels produits le test du micronoyau \u00e9rythrocytaire chez les mammif\u00e8res est-il appropri\u00e9 ?<\/h3><ul><li><a href=\"https:\/\/nano-test.de\/fr\/service\/pharma\/\">Pharmazeutische<\/a> Rohstoffe und Fertigprodukte<\/li><li><a href=\"https:\/\/nano-test.de\/fr\/service\/biozid\/\">Produits biocides<\/a><\/li><li>Pesticides et produits chimiques agricoles<\/li><li>Produits chimiques industriels<\/li><li><a href=\"https:\/\/nano-test.de\/fr\/service\/kosmetik\/\">Kosmetika<\/a> und K\u00f6rperpflegeprodukte<\/li><li><a href=\"https:\/\/nano-test.de\/fr\/service\/lebensmittelanalysen\/\">Lebensmittelzusatzstoffe<\/a> (falls erforderlich)<\/li><\/ul><h3>Pourquoi choisir notre laboratoire ?<\/h3><ul><li>Accr\u00e9ditation GLP et infrastructure de test conforme \u00e0 la TG 474 de l\u2019OCDE<\/li><li>Toxicologues experts et \u00e9quipe de laboratoire exp\u00e9riment\u00e9e<\/li><li>Travailler conform\u00e9ment aux principes \u00e9thiques et aux principes des 3R<\/li><li>Rapports rapides, fiables et conformes<\/li><li>Soutien scientifique dans les processus d\u2019approbation et de R&amp;D<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>OECD-Testrichtlinie 474: Was ist der S\u00e4ugetier-Erythrozyten-Mikronukleus-Test? Zur Bewertung der Sicherheit neu entwickelter pharmazeutischer, biozider oder anderer chemischer Produkte f\u00fcr die Gesundheit von Mensch und Umwelt werden verschiedene toxikologische Tests durchgef\u00fchrt. Einer dieser Tests ist die OECD-Testrichtlinie 474\u00a0\u2013 S\u00e4ugetier-Erythrozyten-Mikronukleus-Test. Dieser im Rahmen der GLP (Gute Laborpraxis) durchgef\u00fchrte Test wird insbesondere verwendet, um das Potenzial von Produkten \u2026 <a href=\"https:\/\/nano-test.de\/fr\/2025\/06\/23\/oecd-474-mammalian-eritrosit-mikronukleustest\/\" class=\"more-link\" title=\"Continue reading &lt;span class=\" screen-reader-text>OECD-Testrichtlinie 474 \u2013 Mammalian-Eritrosit\u00ab\u00a0&gt;Continue reading <span class=\"screen-reader-text\">Directive de test OCDE 474 \u2013 \u00c9rythrosite mammif\u00e8re<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":2248,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-2247","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glp-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>OECD 474 - Mammalian-Eritrosit-Mikronukleustest | GLP | Nano-Test\u00ae<\/title>\n<meta name=\"description\" content=\"Bewertung der Genotoxizit\u00e4t in pharmazeutischen und chemischen Produkten mit dem OECD 474 S\u00e4ugetier-Erythrozyten-Mikronukleustest.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nano-test.de\/2025\/06\/23\/oecd-474-mammalian-eritrosit-mikronukleustest\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OECD 474 - Mammalian-Eritrosit-Mikronukleustest | GLP | Nano-Test\u00ae\" \/>\n<meta property=\"og:description\" content=\"Bewertung der Genotoxizit\u00e4t in pharmazeutischen und chemischen Produkten mit dem OECD 474 S\u00e4ugetier-Erythrozyten-Mikronukleustest.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nano-test.de\/2025\/06\/23\/oecd-474-mammalian-eritrosit-mikronukleustest\/\" \/>\n<meta property=\"og:site_name\" content=\"Nano-Test\u00ae\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-23T14:42:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-01T11:10:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nano-test.de\/wp-content\/uploads\/2025\/06\/OECD-TG-474-Memel-Eritrosit-Mikronukleustest.png\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Sultan Culum\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sultan Culum\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/nano-test.de\\\/2025\\\/06\\\/23\\\/oecd-474-mammalian-eritrosit-mikronukleustest\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nano-test.de\\\/2025\\\/06\\\/23\\\/oecd-474-mammalian-eritrosit-mikronukleustest\\\/\"},\"author\":{\"name\":\"Sultan Culum\",\"@id\":\"https:\\\/\\\/nano-test.de\\\/#\\\/schema\\\/person\\\/e873a4aee4023b424d94f10e41a12670\"},\"headline\":\"OECD-Testrichtlinie 474 &#8211; 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