{"id":2247,"date":"2025-06-23T14:42:41","date_gmt":"2025-06-23T14:42:41","guid":{"rendered":"https:\/\/nano-test.de\/?p=2247"},"modified":"2025-07-01T11:10:58","modified_gmt":"2025-07-01T11:10:58","slug":"oecd-474-mammalian-eritrosit-mikronukleustest","status":"publish","type":"post","link":"https:\/\/nano-test.de\/es\/2025\/06\/23\/oecd-474-mammalian-eritrosit-mikronukleustest\/","title":{"rendered":"Pol\u00edtica de Pruebas de la OCDE 474 &#8211; Eritrosita de mam\u00edferos"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2247\" class=\"elementor elementor-2247\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-24a635ae ts-col-stretched-none ts-bg-color-over-image elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"24a635ae\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5b0f00ff ts-bg-color-over-image\" data-id=\"5b0f00ff\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-62503973 elementor-widget elementor-widget-text-editor\" data-id=\"62503973\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Directriz de prueba de la OCDE 474: \u00bfQu\u00e9 es la prueba de micron\u00facleos de ritrocitos de mam\u00edfero?<\/h2><p>Zur Bewertung der Sicherheit neu entwickelter pharmazeutischer, biozider oder anderer chemischer Produkte f\u00fcr die Gesundheit von Mensch und Umwelt werden verschiedene toxikologische Tests durchgef\u00fchrt. Einer dieser Tests ist die OECD-Testrichtlinie 474<b>\u00a0\u2013 S\u00e4ugetier-Erythrozyten-Mikronukleus-Test<\/b>.<\/p><p>Dieser im Rahmen der <a href=\"https:\/\/nano-test.de\/es\/service\/gute-laborpraxis-glp\/\">GLP (Gute Laborpraxis)<\/a> durchgef\u00fchrte Test wird insbesondere verwendet, um das Potenzial von Produkten zur Sch\u00e4digung des genetischen Materials, d. h. das <b>Genotoxizit\u00e4tsrisiko<\/b>, aufzuzeigen.<\/p><h3>Prop\u00f3sito de la prueba de micron\u00facleos de eritrocitos mamal\u00edes<\/h3><p>Esta prueba examina la formaci\u00f3n de micron\u00facleos (peque\u00f1as estructuras anormales del n\u00facleo) en eritrocitos de la m\u00e9dula \u00f3sea o de la sangre perif\u00e9rica para detectar el da\u00f1o del cromosoma. Los micron\u00facleos surgen de la separaci\u00f3n incorrecta de cromosomas o fragmentos de cromosomas durante la divisi\u00f3n celular y se consideran un indicador de da\u00f1o gen\u00e9tico.<\/p><ul><li>Esta prueba es especialmente preferida en los siguientes casos:<\/li><li>Development process of pharmaceutical products<\/li><li>Evaluaciones de seguridad de productos biocidas y pesticidas<\/li><li>Investigaciones toxicol\u00f3gicas de productos qu\u00edmicos industriales<\/li><li>Casos requeridos para cosm\u00e9ticos o productos de cuidado personal<\/li><\/ul><h3>Proceso de solicitud seg\u00fan la OCDE TG 474<\/h3><p>La prueba de micron\u00facleos realizada de acuerdo con los est\u00e1ndares GLP incluye los siguientes pasos:<\/p><ol><li><b>Vorbereitung der zu testenden Substanz:<\/b>Das Produkt wird unter Festlegung geeigneter L\u00f6sungsmittel und Dosierungsbereiche vorbereitet.<\/li><li><b>Verwendung von Versuchstieren:<\/b>In der Regel werden M\u00e4use oder Ratten verwendet. Vor Beginn der Arbeit wird die Genehmigung der Ethikkommission eingeholt.<\/li><li><b>Exposition:<\/b> Die Testsubstanz wird den Tieren oral, dermal oder durch Inhalation verabreicht.<\/li><li><b>Probenahme:<\/b> Nach einer bestimmten Zeit werden Erythrozytenproben aus dem Knochenmark oder peripherem Blut entnommen.<\/li><li><b>Mikronukleus-Analyse:<\/b> Die Erythrozyten werden unter dem Mikroskop untersucht. Die H\u00e4ufigkeit der Mikronukleusbildung wird bestimmt.<\/li><li><b>Auswertung der Ergebnisse:<\/b> Es wird ein Vergleich mit der Kontrollgruppe durchgef\u00fchrt und eine statistische Analyse vorgenommen.<\/li><\/ol><h3>\u00bfPara qu\u00e9 productos es adecuado la prueba de micron\u00facleos de eritrocitos en mam\u00edferos?<\/h3><ul><li><a href=\"https:\/\/nano-test.de\/es\/service\/pharma\/\">Pharmazeutische<\/a> Rohstoffe und Fertigprodukte<\/li><li><a href=\"https:\/\/nano-test.de\/es\/service\/biozid\/\">Productos biocidas<\/a><\/li><li>Pesticidas y agroqu\u00edmicos<\/li><li>Productos qu\u00edmicos industriales<\/li><li><a href=\"https:\/\/nano-test.de\/es\/service\/kosmetik\/\">Kosmetika<\/a> und K\u00f6rperpflegeprodukte<\/li><li><a href=\"https:\/\/nano-test.de\/es\/service\/lebensmittelanalysen\/\">Lebensmittelzusatzstoffe<\/a> (falls erforderlich)<\/li><\/ul><h3>\u00bfPor qu\u00e9 elegir nuestro laboratorio?<\/h3><ul><li>Acreditaci\u00f3n GLP e infraestructura de prueba conforme a la OCDE TG 474<\/li><li>Toxic\u00f3logos expertos y equipo de laboratorio experimentado<\/li><li>Trabajar de acuerdo con los principios \u00e9ticos y los principios 3R<\/li><li>Informes r\u00e1pidos, fiables y adecuados<\/li><li>Apoyo cient\u00edfico en procesos de admisi\u00f3n e I+D<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>OECD-Testrichtlinie 474: Was ist der S\u00e4ugetier-Erythrozyten-Mikronukleus-Test? Zur Bewertung der Sicherheit neu entwickelter pharmazeutischer, biozider oder anderer chemischer Produkte f\u00fcr die Gesundheit von Mensch und Umwelt werden verschiedene toxikologische Tests durchgef\u00fchrt. Einer dieser Tests ist die OECD-Testrichtlinie 474\u00a0\u2013 S\u00e4ugetier-Erythrozyten-Mikronukleus-Test. Dieser im Rahmen der GLP (Gute Laborpraxis) durchgef\u00fchrte Test wird insbesondere verwendet, um das Potenzial von Produkten \u2026 <a href=\"https:\/\/nano-test.de\/es\/2025\/06\/23\/oecd-474-mammalian-eritrosit-mikronukleustest\/\" class=\"more-link\" title=\"Continue reading &lt;span class=\" screen-reader-text>OECD-Testrichtlinie 474 \u2013 Mammalian-Eritrosit\u00ab&gt;Continue reading <span class=\"screen-reader-text\">Directrices de prueba de la OCDE 474 - Eritrosita de mam\u00edferos<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":2248,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-2247","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glp-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>OECD 474 - Mammalian-Eritrosit-Mikronukleustest | GLP | Nano-Test\u00ae<\/title>\n<meta name=\"description\" content=\"Bewertung der Genotoxizit\u00e4t in pharmazeutischen und chemischen Produkten mit dem OECD 474 S\u00e4ugetier-Erythrozyten-Mikronukleustest.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nano-test.de\/2025\/06\/23\/oecd-474-mammalian-eritrosit-mikronukleustest\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OECD 474 - Mammalian-Eritrosit-Mikronukleustest | GLP | Nano-Test\u00ae\" \/>\n<meta property=\"og:description\" content=\"Bewertung der Genotoxizit\u00e4t in pharmazeutischen und chemischen Produkten mit dem OECD 474 S\u00e4ugetier-Erythrozyten-Mikronukleustest.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nano-test.de\/2025\/06\/23\/oecd-474-mammalian-eritrosit-mikronukleustest\/\" \/>\n<meta property=\"og:site_name\" content=\"Nano-Test\u00ae\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-23T14:42:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-01T11:10:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nano-test.de\/wp-content\/uploads\/2025\/06\/OECD-TG-474-Memel-Eritrosit-Mikronukleustest.png\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Sultan Culum\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sultan Culum\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/nano-test.de\\\/2025\\\/06\\\/23\\\/oecd-474-mammalian-eritrosit-mikronukleustest\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/nano-test.de\\\/2025\\\/06\\\/23\\\/oecd-474-mammalian-eritrosit-mikronukleustest\\\/\"},\"author\":{\"name\":\"Sultan Culum\",\"@id\":\"https:\\\/\\\/nano-test.de\\\/#\\\/schema\\\/person\\\/e873a4aee4023b424d94f10e41a12670\"},\"headline\":\"OECD-Testrichtlinie 474 &#8211; 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