{"id":4141,"date":"2026-03-23T09:17:08","date_gmt":"2026-03-23T09:17:08","guid":{"rendered":"https:\/\/nano-test.de\/?p=4141"},"modified":"2026-03-23T09:26:04","modified_gmt":"2026-03-23T09:26:04","slug":"freisetzungstests-bei-arzneimitteln-pharmazeutische-qualitaet","status":"publish","type":"post","link":"https:\/\/nano-test.de\/en\/2026\/03\/23\/freisetzungstests-bei-arzneimitteln-pharmazeutische-qualitaet\/","title":{"rendered":"Drug release tests: pharmaceutical quality"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4141\" class=\"elementor elementor-4141\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-751f3649 ts-col-stretched-none ts-bg-color-over-image elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"751f3649\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3ae04c80 ts-bg-color-over-image\" data-id=\"3ae04c80\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4f6fb2ae elementor-widget elementor-widget-text-editor\" data-id=\"4f6fb2ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><span style=\"color: #000000;\"><strong>What are drug release tests?<\/strong><\/span><\/h3><p><span style=\"color: #000000;\">Freisetzungstests bei Arzneimitteln sind analytische Tests, mit denen ermittelt wird, wie schnell und in welcher Menge der Wirkstoff eines <a href=\"https:\/\/nano-test.de\/en\/service\/pharma\/\">Arzneimittels<\/a> unter bestimmten Bedingungen in die Umgebung \u00fcbergeht. Diese Tests sind insbesondere f\u00fcr orale feste Darreichungsformen (wie Tabletten oder Kapseln) von gro\u00dfer Bedeutung. Denn die therapeutische Wirkung des Arzneimittels h\u00e4ngt davon ab, dass der Wirkstoff im K\u00f6rper in angemessener Geschwindigkeit und ausreichender Menge freigesetzt wird.<\/span><\/p><h4><span style=\"color: #000000;\"><b>Why are they important?<\/b><\/span><\/h4><p><span style=\"color: #000000;\">Release tests are an indispensable component of drug development and quality control. Thanks to these tests:<\/span><\/p><ul><li><span style=\"color: #000000;\">Preliminary information on the bioavailability of the drug is obtained<\/span><\/li><li><span style=\"color: #000000;\">the batch consistency is ensured<\/span><\/li><li><span style=\"color: #000000;\">Is the effect of formulation changes assessed?<\/span><\/li><li><span style=\"color: #000000;\">the data required for approval procedures are submitted<\/span><\/li><\/ul><p><span style=\"color: #000000;\">Zudem wird die Durchf\u00fchrung dieser Tests von den Zulassungsbeh\u00f6rden (wie <a href=\"https:\/\/www.fda.gov\/\">FDA<\/a>, <a href=\"https:\/\/www.ema.europa.eu\/en\/homepage\">EMA<\/a>) vorgeschrieben.<\/span><\/p><h4><span style=\"color: #000000;\"><strong>Types of Release Tests<\/strong><\/span><\/h4><p><span style=\"color: #000000;\">Depending on the form of dosage and the desired mechanism of action, different release tests are carried out:<\/span><\/p><p><span style=\"color: #000000;\"><strong>1. Immediate Release Tests:<\/strong><\/span><span style=\"color: #000000;\">The active ingredient is expected to dissolve within a short time. As a rule, a resolution of a certain percentage within 30-60 minutes is sought.<\/span><\/p><p><span style=\"color: #000000;\"><strong>2. Controlled Release Tests:<\/strong><\/span><span style=\"color: #000000;\">The active ingredient is released slowly and in a controlled manner over a certain period of time. In this type of tests, analyzes are performed that last several hours.<\/span><\/p><p><span style=\"color: #000000;\"><strong>3. Delayed Release Tests (Delayed Release):<\/strong><\/span><span style=\"color: #000000;\">The aim is that the drug does not dissolve in the stomach but in the intestines. Therefore, the tests are carried out under different pH conditions.<\/span><\/p><h4><span style=\"color: #000000;\"><strong>How is the test carried out?<\/strong><\/span><\/h4><p><span style=\"color: #000000;\">Release tests are usually carried out with special devices, so-called \"dissolution devices\". The most common methods are:<\/span><\/p><ul><li><span style=\"color: #000000;\">Paddle Method<\/span><\/li><li><span style=\"color: #000000;\">Basket Method<\/span><\/li><\/ul><p><span style=\"color: #000000;\">During the test, the tablet or capsule is stirred in a liquid with certain temperature and pH conditions. At certain intervals, samples are taken and the amount of active substance is analyzed.<\/span><\/p><h4><span style=\"color: #000000;\"><strong>The role in pharmaceutical development<\/strong><\/span><\/h4><p><span style=\"color: #000000;\">Release tests in the drug development process:<\/span><\/p><ul><li><span style=\"color: #000000;\">support the wording optimization<\/span><\/li><li><span style=\"color: #000000;\">form the basis for bioequivalence studies<\/span><\/li><li><span style=\"color: #000000;\">bestimmen zusammen mit <a href=\"https:\/\/nano-test.de\/en\/research\/stabilitatstests\/\">Stress tests<\/a> die <a href=\"https:\/\/nano-test.de\/en\/research\/hautreizungstest\/\">Shelf life<\/a> des Produkts<\/span><\/li><\/ul><p><span style=\"color: #000000;\">Therefore, in all phases, from research and development to production, they are considered a decisive quality indicator.<\/span><\/p><p><span style=\"color: #000000;\">Contact us for all questions and analysis processes. info@nano-test.de<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Was sind Freisetzungstests bei Arzneimitteln? Freisetzungstests bei Arzneimitteln sind analytische Tests, mit denen ermittelt wird, wie schnell und in welcher Menge der Wirkstoff eines Arzneimittels unter bestimmten Bedingungen in die Umgebung \u00fcbergeht. Diese Tests sind insbesondere f\u00fcr orale feste Darreichungsformen (wie Tabletten oder Kapseln) von gro\u00dfer Bedeutung. Denn die therapeutische Wirkung des Arzneimittels h\u00e4ngt davon \u2026 <a href=\"https:\/\/nano-test.de\/en\/2026\/03\/23\/freisetzungstests-bei-arzneimitteln-pharmazeutische-qualitaet\/\" class=\"more-link\" title=\"Continue reading &amp;lt;span class=\" screen-reader-text>Freisetzungstests bei Arzneimitteln: Pharmazeutische Qualit\u00e4t\u201c&gt;Continue reading <span class=\"screen-reader-text\">Drug release tests: pharmaceutical quality<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":4143,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-4141","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharma-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Freisetzungstests bei Arzneimitteln: Pharmazeutische Qualit\u00e4t | Nano-Test\u00ae<\/title>\n<meta name=\"description\" content=\"Was sind Freisetzungstests bei Arzneimitteln? 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