{"id":2504,"date":"2025-06-24T17:41:35","date_gmt":"2025-06-24T17:41:35","guid":{"rendered":"https:\/\/nano-test.de\/?p=2504"},"modified":"2025-07-01T11:23:53","modified_gmt":"2025-07-01T11:23:53","slug":"oecd-414-studie-zur-pranatalen-entwicklungstoxizitat","status":"publish","type":"post","link":"https:\/\/nano-test.de\/en\/2025\/06\/24\/oecd-414-studie-zur-pranatalen-entwicklungstoxizitat\/","title":{"rendered":"OECD 414 Prenatal Developmental Toxicity Study"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2504\" class=\"elementor elementor-2504\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6eb789b ts-col-stretched-none ts-bg-color-over-image elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6eb789b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ceb2f18 ts-bg-color-over-image\" data-id=\"ceb2f18\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8345687 elementor-widget elementor-widget-text-editor\" data-id=\"8345687\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><span style=\"color: #000000;\"><strong>OECD Test Guideline 414: What is a Prenatal Developmental Toxicity Study?<\/strong><\/span><\/h3><p><span style=\"color: #000000;\">Entwicklungstoxizit\u00e4tsstudien werden durchgef\u00fchrt, um die Auswirkungen chemischer Substanzen, denen insbesondere w\u00e4hrend der Schwangerschaft ausgesetzt wird, auf Mutter und F\u00f6tus zu verstehen. Der in diesem Zusammenhang erstellte OECD Pr\u00fcfrichtlinie 414<b>\u00a0(Pr\u00e4natale Entwicklungstoxizit\u00e4tsstudie)<\/b> ist eine international anerkannte Standardmethode.<\/span><\/p><blockquote><h3><span style=\"color: #000000;\"><strong>Purpose of the study<\/strong><\/span><\/h3><p><span style=\"color: #000000;\">The OECD Test 414 is used to evaluate a substance used during pregnancy:<\/span><\/p><ul><li><span style=\"color: #000000;\">possible toxic effects on the mother's organism<\/span><\/li><li><span style=\"color: #000000;\">structural abnormalities (malformations), growth retardation or developmental disorders in the embryo or fetus.<\/span><\/li><\/ul><p><span style=\"color: #000000;\">This study plays an important role in both health risk assessment and environmental risk assessment.<\/span><\/p><\/blockquote><h3><span style=\"color: #000000;\"><strong>How is the OECD Test Guideline 414 test performed?<\/strong><\/span><\/h3><p><span style=\"color: #000000;\">This comprehensive study is usually conducted on mammalian species such as rats or rabbits. The basic steps of the test are as follows:<\/span><\/p><ul><li><span style=\"color: #000000;\">The test substance is administered during pregnancy in an appropriate dosage range.<\/span><\/li><li><span style=\"color: #000000;\">The mothers are observed for clinical symptoms, weight changes and behavioural problems.<\/span><\/li><li><span style=\"color: #000000;\">In the last phase of pregnancy, the young animals and the placenta are removed and subjected to a detailed examination.<\/span><\/li><li><span style=\"color: #000000;\">The fetuses are examined for malformations and developmental disorders of the skeleton, internal organs and external structures.<\/span><\/li><\/ul><h3><span style=\"color: #000000;\"><strong>Why is a prenatal developmental toxicity test performed?<\/strong><\/span><\/h3><p><span style=\"color: #000000;\">This test is particularly necessary or recommended for determining the safety profile of products developed in the following areas:<\/span><\/p><ul><li><a href=\"https:\/\/nano-test.de\/en\/service\/pharma\/\"><span style=\"color: #000000;\">Drug development<\/span><\/a><\/li><li><span style=\"color: #000000;\">Assessment of plant protection products and biocidal products<\/span><\/li><li><span style=\"color: #000000;\">Chemical Safety Testing<\/span><\/li><li><span style=\"color: #000000;\">Toxikologische Analysen von <a href=\"https:\/\/nano-test.de\/en\/service\/kosmetik\/\">Kosmetika<\/a><\/span><\/li><\/ul><p><span style=\"color: #000000;\">Due to the sensitivity of development in the womb, early detection of damage that may occur at this stage plays an important role in protecting human health.<\/span><\/p><blockquote><h3><span style=\"color: #000000;\"><strong>Reliable test procedures with Nanolab<\/strong><\/span><\/h3><p><span style=\"color: #000000;\">Bei Nanolab f\u00fchren wir <b><a href=\"https:\/\/translate.google.com\/translate?u=https:\/\/www.oecd.org\/en\/publications\/test-no-414-prenatal-development-toxicity-study_9789264070820-en.html&amp;hl=tr&amp;sl=en&amp;tl=tr&amp;client=srp\">OECD 414<\/a>-Pr\u00fcfungen zur pr\u00e4natalen Entwicklungstoxizit\u00e4t<\/b> gem\u00e4\u00df internationalen Standards durch und ermitteln mit wissenschaftlichen Methoden die potenziellen Risiken Ihrer Produkte f\u00fcr die menschliche Gesundheit. Mit unserem fachkundigen Team und unserer modernen Laborinfrastruktur sorgen wir daf\u00fcr, dass Sie zuverl\u00e4ssige Ergebnisse erhalten.<\/span><\/p><\/blockquote><p>Contact us for all your questions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>OECD Pr\u00fcfrichtlinie 414: Was ist eine pr\u00e4natale Entwicklungstoxizit\u00e4tsstudie? Entwicklungstoxizit\u00e4tsstudien werden durchgef\u00fchrt, um die Auswirkungen chemischer Substanzen, denen insbesondere w\u00e4hrend der Schwangerschaft ausgesetzt wird, auf Mutter und F\u00f6tus zu verstehen. Der in diesem Zusammenhang erstellte OECD Pr\u00fcfrichtlinie 414\u00a0(Pr\u00e4natale Entwicklungstoxizit\u00e4tsstudie) ist eine international anerkannte Standardmethode. Zweck der Studie Der OECD-Test 414 dient dazu, bei einer Substanz, die \u2026 <a href=\"https:\/\/nano-test.de\/en\/2025\/06\/24\/oecd-414-studie-zur-pranatalen-entwicklungstoxizitat\/\" class=\"more-link\" title=\"Continue reading &amp;lt;span class=\" screen-reader-text>OECD 414 Studie zur pr\u00e4natalen Entwicklungstoxizit\u00e4t\u201c&gt;Continue reading <span class=\"screen-reader-text\">OECD 414 Prenatal Developmental Toxicity Study<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":2505,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-2504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glp-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>OECD Pr\u00fcfrichtlinie 414 Pr\u00e4natalen Entwicklungstoxizit\u00e4t |Nano-Test\u00ae<\/title>\n<meta name=\"description\" content=\"F\u00fchren Sie Studien zur pr\u00e4natalen Entwicklungstoxizit\u00e4t sicher gem\u00e4\u00df der OECD-Pr\u00fcfrichtlinie 414 durch. 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