{"id":2494,"date":"2025-06-24T16:21:10","date_gmt":"2025-06-24T16:21:10","guid":{"rendered":"https:\/\/nano-test.de\/?p=2494"},"modified":"2025-07-01T11:20:00","modified_gmt":"2025-07-01T11:20:00","slug":"chromosomenaberrationen-im-knochenmark-von-saugetieren-oecd-475","status":"publish","type":"post","link":"https:\/\/nano-test.de\/en\/2025\/06\/24\/chromosomenaberrationen-im-knochenmark-von-saugetieren-oecd-475\/","title":{"rendered":"Chromosomal aberrations in mammalian bone marrow (OECD 475)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2494\" class=\"elementor elementor-2494\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6c0d8c1 ts-col-stretched-none ts-bg-color-over-image elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6c0d8c1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-10f6c06 ts-bg-color-over-image\" data-id=\"10f6c06\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c687ea2 elementor-widget elementor-widget-text-editor\" data-id=\"c687ea2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><span style=\"color: #000000;\">What is the Chromosomal Aberration Test in Mammalian Bone Marrow (OECD TG 475)?<\/span><\/h3><p><span style=\"color: #000000;\">Genotoxicological studies are a system for assessing the potential of a substance to damage DNA or chromosomes. In this context, OECD TG 475, i.e., the test for chromosomal aberrations in mammalian bone marrow, is a widely used standard test, particularly for determining chromosomal damage in vivo.<\/span><\/p><blockquote><h3><span style=\"color: #000000;\">Purpose and Significance of the Test<\/span><\/h3><p><span style=\"color: #000000;\">This test is used to determine whether a chemical substance causes structural chromosomal aberrations in mammalian bone marrow cells. The data obtained play an important role in understanding the genetic toxicity potential of a substance and thus the risks to human health. The test is particularly used in the development of pharmaceuticals, pesticides, cosmetics, or industrial chemicals.<\/span><\/p><\/blockquote><h3><span style=\"color: #000000;\">Application Process under OECD TG 475<\/span><\/h3><p><span style=\"color: #000000;\">The chromosomal aberration test in mammalian bone marrow is usually performed on rodents. The test process can be summarized as follows:<\/span><\/p><ul><li><span style=\"color: #000000;\">The test substance is administered to the animal at an appropriate dose.<\/span><\/li><li><span style=\"color: #000000;\">After a certain period of time after administration, bone marrow cells are collected.<\/span><\/li><li><span style=\"color: #000000;\">The cells are prepared for microscopic examination.<\/span><\/li><li><span style=\"color: #000000;\">The chromosomes are examined for structural changes (breaks, fragmentation, rearrangement, etc.).<\/span><\/li><li><span style=\"color: #000000;\">The results are compared with those of a control group.<\/span><\/li><\/ul><h3><span style=\"color: #000000;\">Why are in-vivo tests important?<\/span><\/h3><p><span style=\"color: #000000;\"><a style=\"color: #000000;\" href=\"https:\/\/nano-test.de\/en\/research\/in-vitro-tests\/\">In-vitro-Tests<\/a>, die im Labor durchgef\u00fchrt werden, liefern zwar wertvolle Informationen, k\u00f6nnen jedoch die komplexen biologischen Prozesse in einem lebenden Organismus nicht vollst\u00e4ndig widerspiegeln. Daher sind In-vivo-Tests wie OECD 475 f\u00fcr realistische und zuverl\u00e4ssige Risikobewertungen unverzichtbar.<\/span><\/p><blockquote><h3><span style=\"color: #000000;\">What do we offer as Nanolab Laboratory?<\/span><\/h3><p><span style=\"color: #000000;\">As Nanolab, we reliably, quickly, and transparently conduct chromosomal aberration tests according to the international standards of OECD TG 475. With our expert team and modern laboratory infrastructure, we analyze the genetic safety of your products with the utmost care.<\/span><\/p><\/blockquote><h3><span style=\"color: #000000;\">In which areas is it used?<\/span><\/h3><ul><li><span style=\"color: #000000;\">Drug safety<\/span><\/li><li><span style=\"color: #000000;\">Analysis of the toxicity of chemical substances<\/span><\/li><li><span style=\"color: #000000;\">Safety assessment of plant protection products and<\/span><\/li><li><span style=\"color: #000000;\">Biocide products<\/span><\/li><li><span style=\"color: #000000;\">Development processes for cosmetic products<\/span><\/li><li><span style=\"color: #000000;\">Environmental compatibility tests<\/span><\/li><\/ul><p><span style=\"color: #000000;\">Determining the potential of a substance to cause structural changes in genetic material is a crucial step in protecting human health and ensuring product safety. For this reason, the chromosomal aberration test in mammalian bone marrow according to international regulations is a mandatory or recommended test.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Was ist der Chromosomenaberrationstest an S\u00e4ugetierknochenmark (OECD TG 475)? Genotoxikologische Untersuchungen sind ein System zur Bewertung des Potenzials einer Substanz, die DNA oder Chromosomen zu sch\u00e4digen. In diesem Zusammenhang ist die OECD TG 475, d. h. der Test auf chromosomale Aberrationen in S\u00e4ugetierknochenmark, ein weit verbreiteter Standardtest, der insbesondere zur Feststellung von Chromosomensch\u00e4den in vivo \u2026 <a href=\"https:\/\/nano-test.de\/en\/2025\/06\/24\/chromosomenaberrationen-im-knochenmark-von-saugetieren-oecd-475\/\" class=\"more-link\" title=\"Continue reading &amp;lt;span class=\" screen-reader-text>Chromosomenaberrationen im Knochenmark von S\u00e4ugetieren (OECD 475)\u201c&gt;Continue reading <span class=\"screen-reader-text\">Chromosomal aberrations in mammalian bone marrow (OECD 475)<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":2495,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-2494","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glp-blog"],"yoast_head":"<!-- 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